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Last of all, look at where you’re putting your system. Putting your computer on a hard surface will amplify the noise. Putting your computer in a closed space will make it run hotter, in turn forcing fans to work harder. Putting it against walls can also amplify fan noise and heat.
All kinds of soundproofing materials are available that can quiet down your vent system, ranging from a simple foam or rubber mat you can slip underneath to the same high tech foam used in recording studios for the area behind your system.
It might seem obvious, but you should also keep your computer room cool, keep your box out of the sun, and shut down when not in use to ease wear and tear on fans and let your system cool down.